Mathematical Biology Seminar Kresimir Josic, University of Houston Wednesday, November 8, 2023 1:45pm in LCB 323 Title: The Spatio-Temporal Dynamics of Synthetic Microbial Consortia Abstract: Modeling is essential for the design of genetic circuits with desired properties. I will review several examples where mathematical models have been central to the development and understanding of the dynamic of synthetic organisms. I will start with a discussion of synthetic bacterial consortia that exhibit emergent oscillatory behavior - when co-cultured, the interaction between two bacterial strains results in population-level transcriptional oscillations. The spatio-temporal dynamics of such consortia, including synchrony between distant parts of the population, depend sensitively on the architecture of the underlying genetic circuits. I will then describe how spatiotemporal patterns can arise in consortia of cells that individually or collectively exhibit bistable dynamics. I will show how simplified mathematical models can help us understand how order emerges in these system, how patterns can arise, and how they are maintained.